Biobank studies review human biological samples and medical information about patients. The results help to accelerate research studies to find new treatments for diseases such as lymphoma.

If you donate a blood sample, or tissue from a biopsy, it will be kept in a freezer, sometimes for long periods of time. It is usual for patients donating a sample to also complete questionnaires as the samples are more valuable if researches know about the person it comes from.


Observational studies If you are involved in an observational study you may be asked to complete questionnaires about your care and treatment experiences. The information gathered is valuable for ongoing research, it enables researchers to spot trends and important factors which may not have been found otherwise.

 

Below is a list of our current non-drug clinical trials:

PROCLIPI

The PROCLIPI study involves patients with all stages of mycosis fungoides (primary cutaneous T cell lymphoma) and Sézary syndrome. All patients must have been diagnosed for no more than 6 months.

We don’t know why, but in some patients (1 in 5) the skin lymphoma progresses more rapidly. The purpose of this study is to find out why some patients progress more quickly than others. This will allow us to develop a prognostic index which in turn will provide patients and their doctors with more information about their disease.

We are collecting data on patients including information on skin involvement, stage of disease, blood tests, biopsy tests, treatment and quality of life. We may perform future research on blood and skin samples but no additional tests are needed.

MaPLe

The MaPLe study is suitable for patients with suspected or confirmed diffuse large B-cell lymphoma or grade 3b follicular lymphoma. Patients involved in this study can be newly diagnosed or have already received treatment but it has come back.

If you give your consent to be involved in this study, we will seek your permission to perform additional tests on the biopsy that was taken to diagnose your lymphoma. These tests look at the genes in your lymphoma, the process is called molecular profiling. The aim is to find out whether you would be suitable for other treatments with drugs which target gene changes in lymphoma cells.

Molecular profiling may take several weeks to perform and we start the process whilst you undergo further investigations for your lymphoma.

In addition you may be asked for permission for some of your lymphoma sample to be retained for future laboratory research studies.

Real World Data Studies

The Real-World Data studies conducted within the lymphoma team involve the collection of information from patients with lymphoma we have treated in the past or are still being treated.  The main purpose of these studies is to learn more about lymphoma, try and find out which treatments are better for treating patients and provide supporting evidence for new treatments. 

All personal or identifiable information is removed before data is provided for research. The results for studies like these may be submitted for publication in scientific journals around the world, but without disclosing the names or personal information of any patients.

For more information about how your data may be used for research please see The Christie privacy notice and NHS: Your data matters.

If you would like to be involved in any of these trials, email us at: lymphomaclinicaltrials@christie.nhs.uk for more information.