Clinical trials in diffuse large B cell lymphoma

Trial Name

Description

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GEN3013

Phase 1/2 study using antibody GEN3013 to target CD20- expressing cells in patients with B cell non Hodgkin lymphoma

Suitable for patients with B cell non-Hodgkin lymphoma which has come back after previous treatment

ACCEPT

A phase 1b/2 study of acalabrutinib with R-CHOP chemotherapy

Suitable for patients who haven’t yet received any treatment

BI 1206 CRUK CD32b

Phase 1/2a study looking at blocking the CD32b protein with the antibody BI 1206.

Suitable for patients with lymphoma which has come back after previous treatment

ARGO

A phase II study of Atezolizumab with Rituximab, Gemcitabine and Oxaliplatin

Suitable for patients with lymphoma which has come back after previous treatment

IELSG37

A phase 3 study to find out if radiotherapy can be safely omitted in people with primary mediastinal large B-cell lymphoma who are PET negative after chemotherapy.

Suitable for patients who haven't yet received any treatment.

JCAR017

         Phase 2 study determining efficacy and safety of JCAR017

         Suitable for patients with lymphoma which has come back after previous treatment

LYMRIT 37 05

Phase 1 study of the antibody Betalutin® which targets the CD37 antigen.

Suitable for patients with lymphoma which has come back after previous treatment.

MaPLe

Non-medicinal (observational) study involving molecular profiling on patients with suspected or confirmed DLBCL or grade 3b follicular lymphoma

RiVa

Phase 2 trial testing the combination of rituximab and varlilumab in people with high grade and low grade lymphomas

Suitable for patients with lymphoma which has come back after previous treatment

ZUMA-7

Phase 3 trial comparing the CAR T-cell treatment axicabtagene ciloleucel with high-dose chemotherapy and self (autologous) stem cell transplant

Suitable for patients with lymphoma which has come back after previous treatment

ADC-402-201 Loncastuximab tesirine in DLBCL

Phase 2 trial testing the safety and effectiveness of loncastuximab tesirine

Suitable for patients with types of B cell lymphoma which has come back after previous treatment