This information is in addition to your consent form(s) and booklet, 'SACT - a guide for patients and their carers'.
Your treatment
Kadcyla® is made up of two parts that are combined. Trastuzumab (HER2 therapy) is a monoclonal antibody (targeted therapy) and emtansine is an anti-cancer drug, sometimes referred to as chemotherapy.
When trastuzumab attaches to the HER2 protein it allows the emtansine to go into the cancer cell. This drug then becomes active and kills the cancer cell. This action helps to stop the cancer growing or slows its growth.
Kadcyla® is given into the vein (intravenously) through a fine tube (cannula) as an infusion every 3 weeks. The first dose is infused over 90 minutes followed by a 90 minute observational period. The second dose is infused over 30 minutes followed by a 30 minute observational period. Subsequent doses can be given over 30 minutes with no observation period.
The duration of your HER2 directed therapy will depend on your type of breast cancer.
You will have a routine blood test before the start of each treatment. Occasionally we may not be able to go ahead with your treatment until your blood counts are back to a safe level. If this happens, your chemotherapy may be delayed a week.
You may be advised to have a line fitted or an implantable/subcutaneous port (portacath) to aid the delivery of your intravenous treatment. This will be organised by the clinic if it is required. Please ask your team for further information.
Your line or port needs to be removed after all your intravenous treatments have finished. If you have not received an appointment for this, please contact the procedure team on 0161 446 3916.
This treatment can have serious or possibly life-threatening side effects. It is very important that you report side effects straight away.
You are vulnerable to infection while you are having chemotherapy. Minor infections can become life-threatening in a matter of hours if left untreated. Symptoms of infection include fever, shivering, sweats, sore throat, diarrhoea, discomfort when you pass urine, cough or breathlessness. We recommend that you use a digital thermometer so you can check your temperature. You can buy one from your local chemist.
If you feel unwell, you have symptoms of an infection or your temperature is 37.5ºC or above, or below 36ºC, contact The Christie Hotline straight away on 0161 446 3658 (open 24 hours a day, 7 days a week).
Possible side effects
See the Cancer Research UK consent form.
You should have been given a copy of this consent form before you started treatment but it can also be found by visiting www.cancerresearchuk.org and searching ‘Consent forms for SACT (systemic anti-cancer therapy).
See 'SACT - a guide for patients and their carers'.
Contacts
If you have any general questions or concerns about your treatment, please ring:
Administration enquiries: 0161 918 7606/7610
Chemotherapy nurse: 0161 918 7171
Clinical trials unit: 0161 918 7663
If you need the adjuvant HER2 therapy service, please call 0161 446 8001.