Clinical trials in diffuse large B cell lymphoma

The table below shows a list of The Lymphoma Group's current clinical trials open/due to open for recruitment for Diffuse large B-cell lymphoma patients.

If you would like to know how to access our trials please click here

 

Trial Name

 

Description

 

Click the link for more information (external page)

 

GEN3013

 

Phase 1/2 study using antibody GEN3013 to target CD20- expressing cells in patients with B cell non Hodgkin lymphoma


Suitable for patients with B cell non-Hodgkin lymphoma which has come back after previous treatment

 

 

 

ACCEPT

 

A phase 1b/2 study of acalabrutinib with R-CHOP chemotherapy

Suitable for patients who haven’t yet received any treatment

 

 

AZD3965

 

A phase 1 trial looking at a new treatment called AZD3965

Suitable for patients with lymphoma which has come back after previous treatment

 

 

BI 1206 CRUK CD32b

 

Phase 1/2a study looking at blocking the CD32b protein with the antibody BI 1206.

Suitable for patients with lymphoma which has come back after previous treatment

 

 

Epizyme (E7438)

 

Phase 1-2 study looking at new drug Tazemetostat in patients with high grade and low grade lymphoma.

Suitable for patients with DLBCL, FL and PMBCL which has come back after previous treatment

 

 

 

ARGO

 

A phase II study of Atezolizumab with Rituximab, Gemcitabine and Oxaliplatin

Suitable for patients with lymphoma which has come back after previous treatment

 

 

 

IELSG37

 

A phase 3 study to find out if radiotherapy can be safely omitted in people with primary mediastinal large B-cell lymphoma who are PET negative after chemotherapy.

Suitable for patients who haven't yet received any treatment.

 

 

 

G029365 Polatuzumab vedotin

 

Phase 1/2 trial of polatuzumab vedotin, bendamustine and rituximab in people with DLBCL.

Suitable for patients with lymphoma which has come back after previous treatment.

 

 

JCAR017

 

        

         Phase 2 study determining efficacy and safety of JCAR017

         Suitable for patients with lymphoma which has come back after previous treatment

 

 

 

 

POLARIX

 

Phase 3 trial comparing polatuzumab vedotin and vincristine, when given in combination with chemotherapy and antibody therapy


Suitable for patients who haven’t yet received any treatment.

 

 

 

LYMRIT 37 05

 

Phase 1 study of the antibody Betalutin® which targets the CD37 antigen.

Suitable for patients with lymphoma which has come back after previous treatment.

 

 

 

MaPLe

 

Non-medicinal (observational) study involving molecular profiling on patients with suspected or confirmed DLBCL or grade 3b follicular lymphoma

 

 

 

RiVa

 

Phase 2 trial testing the combination of rituximab and varlilumab in people with high grade and low grade lymphomas

Suitable for patients with lymphoma which has come back after previous treatment

 

 

 

ZUMA-7

 

Phase 3 trial comparing the CAR T-cell treatment axicabtagene ciloleucel with high-dose chemotherapy and self (autologous) stem cell transplant

Suitable for patients with lymphoma which has come back after previous treatment

 

 

 

ADC-402-201 Loncastuximab tesirine in DLBCL

 

Phase 2 trial testing the safety and effectiveness of loncastuximab tesirine

Suitable for patients with types of B cell lymphoma which has come back after previous treatment

 

 

 

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