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Dr Makin initially trained as a clinical oncologist at The Christie. Following this she gained 5 years experience based as a  consultant based at St Oswald's Hospice in Newcastle upon Tyne, before returning to Manchester in 1995. She led the development of the multidisciplinary palliative care service at The Christie and helped to establish higher specialist training in palliative medicine in Greater Manchester. Wendy was Deputy Medical Director and Responsible Officer from 2011-16

Wendy led a cross-College working party into the urgent care needs of people with cancer in 2012-13 and chaired the palliative medicine specialty committee at the Royal College of Physicians from 2013-16 and was a member of the Joint Collegiate council for Oncology.

For several years she has been engaged in the development of support and information for cancer survivors and took up the new Manchester Cancer pathway director for Living With and Beyond Cancer (LWBC) in 2014. Wendy has been working with the Macmillan Cancer Improvement Project to improve services across the city of Manchester and leads of the LWBC work streams in the National Cancer Vanguard.

Wendy is a member of the Macmillan consultant advisory group, working closely with the Macmillan GP network and a member of the Macmillan Cancer Support clinical advisory board.